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Servant G, et al.  (2012) Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress. Nucleic Acids Res 40(12):5271-82

Abstract: Transposable elements play a fundamental role in genome evolution. It is proposed that their mobility, activated under stress, induces mutations that could confer advantages to the host organism. Transcription of the Ty1 LTR-retrotransposon of Saccharomyces cerevisiae is activated in response to a severe deficiency in adenylic nucleotides. Here, we show that Ty2 and Ty3 are also stimulated under these stress conditions, revealing the simultaneous activation of three active Ty retrotransposon families. We demonstrate that Ty1 activation in response to adenylic nucleotide depletion requires the DNA-binding transcription factor Tye7. Ty1 is transcribed in both sense and antisense directions. We identify three Tye7 potential binding sites in the region of Ty1 DNA sequence where antisense transcription starts. We show that Tye7 binds to Ty1 DNA and regulates Ty1 antisense transcription. Altogether, our data suggest that, in response to adenylic nucleotide reduction, TYE7 is induced and activates Ty1 mRNA transcription, possibly by controlling Ty1 antisense transcription. We also provide the first evidence that Ty1 antisense transcription can be regulated by environmental stress conditions, pointing to a new level of control of Ty1 activity by stress, as Ty1 antisense RNAs play an important role in regulating Ty1 mobility at both the transcriptional and post-transcriptional stages.

Status: Published Type: Journal Article PubMed ID: 22379133

Topics addressed in this paper

Number of different genes curated to this paper: 137

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADK1 BAS1 PHO2 TYE7 YAR009C YAR010C YARCTy1-1 YBL005W-A YBL005W-B YBL100W-A
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Genetic Interactions blue ball blue ball blue ball
Genomic expression study yg ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Omics yg ball
Primary Literature blue ball
Protein-Nucleic Acid Interactions blue ball
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Regulatory Role blue ball
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Topics Genes linked to topics (#11 - 20 )
YBL100W-B YBLWTy1-1 YBLWTy2-1 YBR012W-A YBR012W-B YBRWTy1-2 YCL019W YCL020W YCLWTy2-1 YDR034C-C
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Topics Genes linked to topics (#21 - 30 )
YDR034C-D YDR098C-A YDR098C-B YDR170W-A YDR210C-C YDR210C-D YDR210W-A YDR210W-B YDR261C-C YDR261C-D
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Topics Genes linked to topics (#31 - 40 )
YDR261W-A YDR261W-B YDR316W-A YDR316W-B YDR365W-A YDR365W-B YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRCTy2-1
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Topics Genes linked to topics (#41 - 50 )
YDRWTy1-4 YDRWTy1-5 YDRWTy2-2 YDRWTy2-3 YER137C-A YER138C YER159C-A YER160C YERCTy1-1 YERCTy1-2
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Topics Genes linked to topics (#51 - 60 )
YFL002W-A YFL002W-B YFLWTy2-1 YGR027W-A YGR027W-B YGR038C-A YGR038C-B YGR109W-A YGR109W-B YGR161C-C
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
YGR161C-D YGR161W-A YGR161W-B YGRCTy1-2 YGRCTy1-3 YGRCTy2-1 YGRWTy1-1 YGRWTy2-2 YGRWTy3-1 YHR214C-B
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Topics Genes linked to topics (#71 - 80 )
YHR214C-C YHRCTy1-1 YIL080W YIL082W YIL082W-A YILWTy3-1 YJR026W YJR027W YJR028W YJR029W
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#81 - 90 )
YJRWTy1-1 YJRWTy1-2 YLR035C-A YLR157C-A YLR157C-B YLR227W-A YLR256W-A YLR410W-A YLR410W-B YLRCTy1-1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#91 - 100 )
YLRCTy2-2 YLRWTy1-2 YLRWTy1-3 YLRWTy2-1 YML039W YML040W YML045W YML045W-A YMLWTy1-1 YMLWTy1-2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#101 - 110 )
YMR045C YMR046C YMR050C YMR051C YMRCTy1-3 YMRCTy1-4 YNL054W-A YNL054W-B YNL284C-A YNL284C-B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#111 - 120 )
YNLCTy1-1 YNLCTy2-1 YNLWTy1-2 YOL103W-A YOL103W-B YOLWTy1-1 YOR142W-A YOR142W-B YOR192C-A YOR192C-B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#121 - 130 )
YOR343W-A YOR343W-B YORCTy2-1 YORWTy1-2 YORWTy2-2 YPL257W-A YPL257W-B YPLWTy1-1 YPR137C-A YPR137C-B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#131 - 137 )
YPR158C-C YPR158C-D YPR158W-A YPR158W-B YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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