Simmons Kovacs LA, et al. (2012) Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. Mol Cell 45(5):669-79
Abstract: During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex, incorporating multiple G1, S phase, and mitotic cyclin-CDK complexes. However, periodic events persist in yeast cells lacking all S phase and mitotic B-cyclin genes, challenging the assertion that cyclin-CDK complexes are essential for oscillations. These and other results led to the proposal that a network of sequentially activated transcription factors functions as an underlying cell-cycle oscillator. Here we examine the individual contributions of a transcription factor network and cyclin-CDKs to the maintenance of cell-cycle oscillations. Our findings suggest that while cyclin-CDKs are not required for oscillations, they do contribute to oscillation robustness. A model emerges in which cyclin expression (thereby, CDK activity) is entrained to an autonomous transcriptional oscillator. CDKs then modulate oscillator function and serve as effectors of the oscillator.
|Status: Published||Type: Journal Article||PubMed ID: 22306294|
Topics addressed in this paper
Number of different genes curated to this paper: 14
- To go to the Locus page for a gene, click on the gene name.
|Topics||Topics not linked to Genes||Genes (#1 - 10 )|
|Cell Cycle Phase Involved|
|Other genomic analysis|
|Topics||Genes (#11 - 14 )|