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Cremona CA, et al.  (2012) Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell 45(3):422-32

Abstract: The cellular response to DNA damage employs multiple dynamic protein modifications to exert rapid and adaptable effects. Substantial work has detailed the roles of canonical checkpoint-mediated phosphorylation in this program. Recent studies have also implicated sumoylation in the DNA damage response; however, a systematic view of the contribution of sumoylation to replication and repair and its interplay with checkpoints is lacking. Here, using a biochemical screen in yeast, we establish that DNA damage-induced sumoylation occurs on a large scale. We identify MRX (Mre11-Rad50-Xrs2) as a positive regulator of this induction for a subset of repair targets. In addition, we find that defective sumoylation results in failure to complete replication of a damaged genome and impaired DNA end processing, highlighting the importance of the SUMO-mediated response in genome integrity. We also show that DNA damage-induced sumoylation does not require Mec1 checkpoint signaling, and the presence of both enables optimal DNA damage resistance.

Status: Published Type: Journal Article PubMed ID: 22285753

Topics addressed in this paper

Number of different genes curated to this paper: 73

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Topics Genes linked to topics (#1 - 10 )
ABF1 APN1 DDC1 DPB11 DUN1 LIF1 MAG1 MCM2 MCM4 MCM5
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Topics Genes linked to topics (#11 - 20 )
MCM6 MEC1 MGS1 MLH1 MMS21 MRE11 MSH3 MSH6 NFI1 NTG1
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Topics Genes linked to topics (#21 - 30 )
OGG1 ORC2 ORC3 ORC4 ORC6 PIF1 PMS1 POB3 POL1 POL12
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Topics Genes linked to topics (#31 - 40 )
POL2 POL30 POL32 PRI1 PRI2 PSO2 RAD1 RAD16 RAD2 RAD27
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Topics Genes linked to topics (#41 - 50 )
RAD3 RAD4 RAD5 RAD50 RAD52 RAD59 RAD7 RFA1 RFA2 RFC1
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Topics Genes linked to topics (#51 - 60 )
RFC2 RFC3 RTT107 SAE2 SAW1 SGS1 SIZ1 SLX4 SMC5 SMC6
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Topics Genes linked to topics (#61 - 70 )
SRS2 SSL1 SSL2 TEL1 TFB2 TOF2 TOP1 TOP2 UBC9 XRS2
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Topics Genes linked to topics (#71 - 73 )
YEN1 YKU70 YKU80
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