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Benitez EM, et al.  (2011) Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett 585(19):3015-9

Abstract: The endoplasmic reticulum (ER) is responsible for folding and delivery of secretory proteins to their site of action. One major modification proteins undergo in this organelle is N-glycosylation. Proteins that cannot fold properly will be directed to a process known as endoplasmic reticulum associated degradation (ERAD). Processing of N-glycans generates a signal for ERAD. The lectin Yos9 recognizes the N-glycan signal of misfolded proteins and acts as a gatekeeper for the delivery of these substrates to the cytoplasm for degradation. Presence of Yos9 accelerates degradation of the glycosylated model ERAD substrate CPY *. Here we show that Yos9 has also a control function in degradation of the unglycosylated ERAD substrate CPY *0000. It decelerates its degradation rate.CI - Copyright (c) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 21871892

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Topics Genes linked to topics (#1 - 10 )
DER1 DOA1 HRD1 MNL1 PEP4 PRB1 PRC1 PRE1 PRE4 USA1
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Topics Genes linked to topics (#11 )
YOS9
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