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Cuylen S and Haering CH  (2011) Deciphering condensin action during chromosome segregation. Trends Cell Biol 21(9):552-9

Abstract: The correct segregation of eukaryotic genomes requires the resolution of sister DNA molecules and their movement into opposite halves of the cell before cell division. The dynamic changes chromosomes need to undergo during these events depend on the action of a multi-subunit SMC (structural maintenance of chromosomes) protein complex named condensin, but its molecular function in chromosome segregation is still poorly understood. Recent studies suggest that condensin has a role in the removal of sister chromatid cohesin, in sister chromatid decatenation by topoisomerases, and in the structural reconfiguration of mitotic chromosomes. In this review we discuss possible mechanisms that could explain the variety of condensin actions during chromosome segregation.CI - Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't | Review PubMed ID: 21763138

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BRN1 IRR1 MCD1 SMC1 SMC2 SMC3 SMC4 TFC3 YCG1 YCS4
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