Parnell EJ and Stillman DJ (2011) Shields up: the Tup1-Cyc8 repressor complex blocks coactivator recruitment. Genes Dev 25(23):2429-35
Abstract: The Tup1-Cyc8 complex is responsible for repression of a large and diverse collection of genes in Saccharomyces cerevisiae. The predominant view has been that Tup1-Cyc8 functions as a corepressor, actively associating with regulatory proteins and organizing chromatin to block transcription. A new study by Wong and Struhl in this issue of Genes & Development (pp. 2525-2539) challenges nearly 20 years of models by demonstrating that Tup1-Cyc8 functions primarily as a shield to block DNA-binding proteins from recruiting transcriptional coactivators.
|Status: Published||Type: Journal Article||PubMed ID: 22156205|
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