Grun B, et al. (2012) Modelling time course gene expression data with finite mixtures of linear additive models. Bioinformatics 28(2):222-8
Abstract: A model class of finite mixtures of linear additive models is presented. The component-specific parameters in the regression models are estimated using regularized likelihood methods. The advantages of the regularization are that (i) the pre-specified maximum degrees of freedom for the splines is less crucial than for unregularized estimation and that (ii) for each component individually a suitable degree of freedom is selected in an automatic way. The performance is evaluated in a simulation study with artificial data as well as on a yeast cell cycle dataset of gene expression levels over time. AVAILABILITY: The latest release version of the R package flexmix is available from CRAN (http://cran.r-project.org/).
|Status: Published||Type: Journal Article||PubMed ID: 22121159|
Topics addressed in this paper
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|Topics||Topics not linked to Genes|