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Ben-Shem A, et al.  (2011) The structure of the eukaryotic ribosome at 3.0 ? resolution. Science 334(6062):1524-9

Abstract: Ribosomes translate genetic information encoded by messenger RNA into proteins. Many aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are much larger and intricate than their bacterial counterparts. We report the crystal structure of the 80S ribosome from the yeast Saccharomyces cerevisiae--including nearly all ribosomal RNA bases and protein side chains as well as an additional protein, Stm1--at a resolution of 3.0 angstroms. This atomic model reveals the architecture of eukaryote-specific elements and their interaction with the universally conserved core, and describes all eukaryote-specific bridges between the two ribosomal subunits. It forms the structural framework for the design and analysis of experiments that explore the eukaryotic translation apparatus and the evolutionary forces that shaped it.

Status: Published Type: Journal Article PubMed ID: 22096102

Topics addressed in this paper

Number of different genes curated to this paper: 111

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Topics Genes linked to topics (#1 - 10 )
ANB1 ARD1 ARX1 ASC1 BUD27 FES1 GCN1 GCN2 GCN20 HEF3
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Topics Genes linked to topics (#11 - 20 )
HYP2 JJJ1 MAP1 NAT1 NAT5 NIP7 NMD3 RDN18-1 RDN18-2 RDN25-1
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Topics Genes linked to topics (#21 - 30 )
RDN25-2 RDN5-1 RDN5-2 RDN5-3 RDN5-4 RDN5-5 RDN5-6 RDN58-1 RDN58-2 REH1
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Topics Genes linked to topics (#31 - 40 )
REI1 RLI1 RPL10 RPL11A RPL11B RPL12A RPL12B RPL13A RPL13B RPL14A
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Topics Genes linked to topics (#41 - 50 )
RPL14B RPL15A RPL15B RPL16A RPL16B RPL17A RPL17B RPL18A RPL18B RPL19A
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Topics Genes linked to topics (#51 - 60 )
RPL19B RPS0A RPS0B RPS10A RPS10B RPS11A RPS11B RPS12 RPS13 RPS14A
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Topics Genes linked to topics (#61 - 70 )
RPS14B RPS15 RPS16A RPS16B RPS17A RPS17B RPS18A RPS18B RPS19A RPS19B
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Topics Genes linked to topics (#71 - 80 )
RPS1A RPS1B RPS2 RPS20 RPS21A RPS21B RPS22A RPS22B RPS23A RPS23B
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Topics Genes linked to topics (#81 - 90 )
RPS24A RPS24B RPS25A RPS25B RPS26A RPS26B RPS27A RPS27B RPS28A RPS28B
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Topics Genes linked to topics (#91 - 100 )
RPS29A RPS29B RPS3 RPS30A RPS30B RPS31 RPS4A RPS4B RPS5 RPS6A
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Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#101 - 110 )
RPS6B RPS7A RPS7B RPS8A RPS8B RPS9A RPS9B SQT1 STM1 YEF3
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Topics Genes linked to topics (#111 )
YGR054W
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Protein/Nucleic Acid Structure blue ball

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