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Sarma NJ, et al.  (2011) The nuclear pore complex mediates binding of the mig1 repressor to target promoters. PLoS One 6(11):e27117

Abstract: All eukaryotic cells alter their transcriptional program in response to the sugar glucose. In Saccharomyces cerevisiae, the best-studied downstream effector of this response is the glucose-regulated repressor Mig1. We show here that nuclear pore complexes also contribute to glucose-regulated gene expression. NPCs participate in glucose-responsive repression by physically interacting with Mig1 and mediating its function independently of nucleocytoplasmic transport. Surprisingly, despite its abundant presence in the nucleus of glucose-grown nup120Delta or nup133Delta cells, Mig1 has lost its ability to interact with target promoters. The glucose repression defect in the absence of these nuclear pore components therefore appears to result from the failure of Mig1 to access its consensus recognition sites in genomic DNA. We propose that the NPC contributes to both repression and activation at the level of transcription.

Status: Published Type: Journal Article PubMed ID: 22110603

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Topics Genes linked to topics
GCR1 MIG1 NUP120 NUP133 NUP42 NUP53 NUP84 SUC2
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