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Horowitz DS  (2011) The mechanism of the second step of pre-mRNA splicing. Wiley Interdiscip Rev RNA 3(3):331-50

Abstract: The molecular mechanisms of the second step of pre-mRNA splicing in yeast and higher eukaryotes are reviewed. The important elements in the pre-mRNA, the participating proteins, and the proposed secondary structures and roles of the snRNAs are described. The sequence of events in the second step is presented, focusing on the actions of the proteins in setting up and facilitating the second reaction. Mechanisms for avoiding errors in splicing are discussed.

Status: Published Type: Journal Article PubMed ID: 22012849

Topics addressed in this paper

Number of different genes curated to this paper: 16

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Topics Genes linked to topics (#1 - 10 )
BRR2 CDC40 ISY1 LSR1 NTR2 PRP16 PRP18 PRP22 PRP43 PRP8
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Topics Genes linked to topics (#11 - 16 )
SLU7 SNR6 SNR7-L SNR7-S SNU114 SPP382
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