SGD Paper Help


Page Contents:
Chittuluru JR, et al.  (2011) Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes.LID - 10.1038/nsmb.2128 [doi] Nat Struct Mol Biol ()

Abstract: We have used EM and biochemistry to characterize the structure of NuA4, an essential yeast histone acetyltransferase (HAT) complex conserved throughout eukaryotes, and we have determined the interaction of NuA4 with the nucleosome core particle (NCP). The ATM-related Tra1 subunit, which is shared with the SAGA coactivator complex, forms a large domain joined to a second region that accommodates the catalytic subcomplex Piccolo and other NuA4 subunits. EM analysis of a NuA4-NCP complex shows the NCP bound at the periphery of NuA4. EM characterization of Piccolo and Piccolo-NCP provided further information about subunit organization and confirmed that histone acetylation requires minimal contact with the NCP. A small conserved region at the N terminus of Piccolo subunit enhancer of Polycomb-like 1 (Epl1) is essential for NCP interaction, whereas the subunit yeast homolog of mammalian Ing1 2 (Yng2) apparently positions Piccolo for efficient acetylation of histone H4 or histone H2A tails. Taken together, these results provide an understanding of the NuA4 subunit organization and the NuA4-NCP interactions.

Status: Epub ahead of print Type: Journal Article PubMed ID: 21984211

Topics addressed in this paper

Number of different genes curated to this paper: 40

Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Genes linked to topics (#1 - 10 )
ACT1 ADA2 ARP4 CHD1 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1
Additional Literature blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
Strains/Constructs blue ball blue ball
Techniques and Reagents blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
ESA1 GCN5 HFI1 HHF1 HHF2 HHT1 HHT2 HTA1 HTA2 HTB1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Protein Physical Properties blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein/Nucleic Acid Structure blue ball blue ball blue ball
Regulation of blue ball
Techniques and Reagents blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
HTB2 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 SUS1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball
Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Techniques and Reagents blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#31 - 40 )
SWC4 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1 UBP8 YAF9 YNG2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball
Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
Strains/Constructs blue ball
Techniques and Reagents blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: