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Peng J and Zhou JQ  (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Res 40(2):581-93

Abstract: Eukaryotic chromosome ends have a DNA-protein complex structure termed telomere. Integrity of telomeres is essential for cell proliferation. Genome-wide screenings for telomere length maintenance genes identified several components of the transcriptional regulator, the Mediator complex. Our work provides evidence that Mediator is involved in telomere length regulation and telomere heterochromatin maintenance. Tail module of Mediator is required for telomere silencing by promoting or stabilizing Sir protein binding and spreading on telomeres. Mediator binds on telomere and may be a component of telomeric chromatin. Our study reveals a specific role of Mediator complex at the heterochromatic telomere and this function is specific to telomeres as it has no effect on the HMR locus.

Status: Published Type: Journal Article PubMed ID: 21930512

Topics addressed in this paper

Number of different genes curated to this paper: 35

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Topics Genes linked to topics (#1 - 10 )
CDC13 CDC73 CSE2 EST1 EST2 EST3 GAL11 HHF1 HHF2 HMRA1
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Topics Genes linked to topics (#11 - 20 )
LEO1 MED1 MED2 NUT1 PGD1 RAP1 RIF1 RIF2 ROX3 SAS2
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Topics Genes linked to topics (#21 - 30 )
SAS4 SAS5 SIN4 SIR2 SIR3 SIR4 SRB2 SRB5 SRB8 SSN2
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Topics Genes linked to topics (#31 - 35 )
SSN3 SSN8 TLC1 YKU70 YKU80
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