Palermo V, et al. (2011) Drug-induced inhibition of tubulin polymerization induces mitochondrion-mediated apoptosis in yeast. Cell Cycle 10(18):3208-9
Abstract: Yeast represents a very powerful tool also for finding new therapeutic drugs and their mechanism of action. Here we report that cytotoxicity of an anticancer drug derived from the tubulin assembly inhibitors Arylthioindoles (ATIs) is rescued by deletion of DNM1, MDM30, AIF1, NUC1 and YCA1 genes, suggesting that this compound acts through the induction of mitochondrion-mediated apoptosis.
|Status: Published||Type: Journal Article||PubMed ID: 21912212|
Topics addressed in this paper
Number of different genes curated to this paper: 5
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