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North M, et al.  (2011) Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One 6(8):e24205

Abstract: Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene toxicity difficult. We used a functional genomics approach to identify the genes that modulate the cellular toxicity of three of the phenolic metabolites of benzene, hydroquinone (HQ), catechol (CAT) and 1,2,4-benzenetriol (BT), in the model eukaryote Saccharomyces cerevisiae. Benzene metabolites generate oxidative and cytoskeletal stress, and tolerance requires correct regulation of iron homeostasis and the vacuolar ATPase. We have identified a conserved bZIP transcription factor, Yap3p, as important for a HQ-specific response pathway, as well as two genes that encode putative NAD(P)H:quinone oxidoreductases, PST2 and YCP4. Many of the yeast genes identified have human orthologs that may modulate human benzene toxicity in a similar manner and could play a role in benzene exposure-related disease.

Status: Published Type: Journal Article PubMed ID: 21912624

Topics addressed in this paper

Number of different genes curated to this paper: 86

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Topics Genes linked to topics (#1 - 10 )
AFT1 ALF1 ARO2 ARO9 ARP1 ATG15 BCH1 CDC26 CLD1 CSR1
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Topics Genes linked to topics (#11 - 20 )
DST1 FMP25 FRE8 GLR1 GSH1 HAT2 HOG1 HRD1 HYR1 IRA2
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Topics Genes linked to topics (#21 - 30 )
IRC2 ISC1 LAG2 LOT6 LPX1 LYS20 MAC1 MRS4 NCR1 NFU1
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Topics Genes linked to topics (#31 - 40 )
NUP53 PAN2 PDX3 PET10 PHO13 PST2 PXA1 RFS1 RPE1 RPN4
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Topics Genes linked to topics (#41 - 50 )
SFK1 SHS1 SKN7 SLT2 SPP1 SUC2 SWE1 TKL1 TOM1 TSA1
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Topics Genes linked to topics (#51 - 60 )
UBC7 USV1 VAM10 VAM7 VMA22 VMA3 VMA5 VMA8 VPH2 VPS21
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Topics Genes linked to topics (#61 - 70 )
VPS3 VPS51 VPS8 YAP1 YAP3 YBP1 YBR292C YCL007C YCP4 YDL211C
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Topics Genes linked to topics (#71 - 80 )
YGR117C YGR130C YGR139W YHL026C YJL120W YKL071W YKL123W YKL133C YKL147C YKL222C
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Topics Genes linked to topics (#81 - 86 )
YKR033C YOL079W YOL085C YOR325W YOR331C YPR076W
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