Batenchuk C, et al. (2011) Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size. Biophys J 100(10):L56-8
Abstract: Gene expression noise varies with genomic position and is a driving force in the evolution of chromosome organization. Nevertheless, position effects remain poorly characterized. Here, we present a systematic analysis of chromosomal position effects by characterizing single-cell gene expression from euchromatic positions spanning the length of a eukaryotic chromosome. We demonstrate that position affects gene expression by modulating the size of transcriptional bursts, rather than their frequency, and that the histone deacetylase Sir2 plays a role in this process across the chromosome.CI - Copyright (c) 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 21575565|
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|Genomic expression study|