SGD Paper 
Kwan EX, et al. (2011) Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast. PLoS Genet 7(8):e1002250
Abstract: Aging and longevity are considered to be highly complex genetic traits. In order to gain insight into aging as a polygenic trait, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard strain RM11 and a laboratory strain S288c, to identify quantitative trait loci that control chronological lifespan. Among the major loci that regulate chronological lifespan in this cross, one genetic linkage was found to be congruent with a previously mapped locus that controls telomere length variation. We found that a single nucleotide polymorphism in BUL2, encoding a component of an ubiquitin ligase complex involved in trafficking of amino acid permeases, controls chronological lifespan and telomere length as well as amino acid uptake. Cellular amino acid availability changes conferred by the BUL2 polymorphism alter telomere length by modulating activity of a transcription factor Gln3. Among the GLN3 transcriptional targets relevant to this phenotype, we identified Wtm1, whose upregulation promotes nuclear retention of ribonucleotide reductase (RNR) components and inhibits the assembly of the RNR enzyme complex during S-phase. Inhibition of RNR is one of the mechanisms by which Gln3 modulates telomere length. Identification of a polymorphism in BUL2 in this outbred yeast population revealed a link among cellular amino acid availability, chronological lifespan, and telomere length control.
| Status: Published | Type: Journal Article | PubMed ID: 21901113 |
Topics addressed in this paper
Number of different genes curated to this paper: 9
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
| Topics | Topics not linked to Genes | Genes linked to topics | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BUL2 | GLN3 | RNR4 | TEL1 | TLC1 | TOR1 | URE2 | WTM1 | YKU70 | ||
| Additional Literature |  | | | | | |||||
| Cell Cycle Phase Involved | | |||||||||
| Cell Growth and Metabolism | 
| |||||||||
| Cellular Location | | |||||||||
| Function/Process | | | ||||||||
| Fungal Related Genes/Proteins | | |||||||||
| Genetic Interactions | | | | | | |||||
| Mutants/Phenotypes | | | | | | | | |||
| Omics |
| |||||||||
| Other genomic analysis |
| |||||||||
| Primary Literature | | | | | ||||||
| Protein Sequence Features | | |||||||||
| Regulation of | | | ||||||||
| Regulatory Role | | | | | ||||||
| Strains/Constructs | | | | | | | | |||
