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Delaney JR, et al.  (2011) Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell 10(6):1089-91

Abstract: Activation of Sir2 orthologs is proposed to increase lifespan downstream of dietary restriction. Here, we describe an examination of the effect of 32 different lifespan-extending mutations and four methods of DR on replicative lifespan (RLS) in the short-lived sir2? yeast strain. In every case, deletion of SIR2 prevented RLS extension; however, RLS extension was restored when both SIR2 and FOB1 were deleted in several cases, demonstrating that SIR2 is not directly required for RLS extension. These findings indicate that suppression of the sir2? lifespan defect is a rare phenotype among longevity interventions and suggest that sir2? cells senesce rapidly by a mechanism distinct from that of wild-type cells. They also demonstrate that failure to observe lifespan extension in a short-lived background, such as cells or animals lacking sirtuins, should be interpreted with caution.

Status: Published Type: Journal Article PubMed ID: 21902802

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Genes linked to topics (#1 - 10 )
AFG3 ALG12 DBP3 ELP4 FOB1 GPA2 HXK2 IDH1 IDH2 INP51
Genetic Interactions blue ball
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Topics Genes linked to topics (#11 - 20 )
MSW1 MTC4 REI1 RIM1 RPL13A RPL21B RPL22A RPL23A RPL37B RPL43B
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
RPL7A RPP2B SAM1 SAS2 SCH9 SIP2 SIR2 SPS1 TIF2 TIS11
Additional Literature blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 34 )
TMA19 TOR1 URE2 YBR238C
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