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Molin M, et al.  (2011) Life Span Extension and H(2)O(2) Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae. Mol Cell 43(5):823-33

Abstract: Caloric restriction (CR) extends the life span of organisms ranging from yeast to primates. Here, we show that the thiol-dependent peroxiredoxin Tsa1 and its partner sulfiredoxin, Srx1, are required for CR to extend the replicative life span of yeast cells. Tsa1 becomes hyperoxidized/inactive during aging, and CR mitigates such oxidation by elevating the levels of Srx1, which is required to reduce/reactivate hyperoxidized Tsa1. CR, by lowering cAMP-PKA activity, enhances Gcn2-dependent SRX1 translation, resulting in increased resistance to H(2)O(2) and life span extension. Moreover, an extra copy of the SRX1 gene is sufficient to extend the life span of cells grown in high glucose concentrations by 20% in a Tsa1-dependent and Sir2-independent manner. The data demonstrate that Tsa1 is required to ensure yeast longevity and that CR extends yeast life span, in part, by counteracting age-induced hyperoxidation of this peroxiredoxin.CI - Copyright (c) 2011 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article PubMed ID: 21884982

Topics addressed in this paper

Number of different genes curated to this paper: 25

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Topics Genes linked to topics (#1 - 10 )
CDC25 CYR1 DCS1 ERG6 FOB1 GCN2 GCN4 GPA2 GPR1 MSN2
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Topics Genes linked to topics (#11 - 20 )
MSN4 PDE2 RAS2 REG1 SIR2 SKN7 SRX1 TEF4 TOR1 TPK2
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Topics Genes linked to topics (#21 - 25 )
TRR1 TRX1 TRX2 TSA1 YAP1
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