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Panizza S, et al.  (2011) Spo11-accessory proteins link double-strand break sites to the chromosome axis in early meiotic recombination. Cell 146(3):372-83

Abstract: Meiotic recombination between homologous chromosomes initiates via programmed DNA double-strand breaks (DSBs), generated by complexes comprising Spo11 transesterase plus accessory proteins. DSBs arise concomitantly with the development of axial chromosome structures, where the coalescence of axis sites produces linear arrays of chromatin loops. Recombining DNA sequences map to loops, but are ultimately tethered to the underlying axis. How and when such tethering occurs is currently unclear. Using ChIPchip in yeast, we show that Spo11-accessory proteins Rec114, Mer2, and Mei4 stably interact with chromosome axis sequences, upon phosphorylation of Mer2 by S phase Cdk. This axis tethering requires meiotic axis components (Red1/Hop1) and is modulated in a domain-specific fashion by cohesin. Loss of Rec114, Mer2, and Mei4 binding correlates with loss of DSBs. Our results strongly suggest that hotspot sequences become tethered to axis sites by the DSB machinery prior to DSB formation.CI - Copyright (c) 2011 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article PubMed ID: 21816273

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
CLB5 CLB6 HOP1 MEI4 REC102 REC104 REC107 REC114 REC8 RED1
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Topics Genes linked to topics (#11 - 12 )
SPO11 ZIP1
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