Mizushima N, et al. (2011) The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 27():107-32
Abstract: Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.
|Status: Published||Type: Journal Article||PubMed ID: 21801009|
Topics addressed in this paper
Number of different genes curated to this paper: 21
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|Topics||Genes (#21 )|