Cui XJ, et al. (2011) Combinatorial patterns of histone modifications in Saccharomyces cerevisiae. Yeast 28(9):683-91
Abstract: Histone modification is an important subject of epigenetics that plays an intrinsic role in transcriptional regulation. It has been suggested that multiple histone modifications act in a combinatorial fashion to form a 'histone code'. In this study, the combinatorial patterns of histone modifications were studied by using a Bayesian network at the level of individual nucleosomes in S. cerevisiae. Our results indicated that there were 23 combinatorial patterns for 12 histone modifications investigated when a general Bayesian network was constructed. Meanwhile, different networks were also constructed for the genes with high transcript levels (H-network) and low transcript levels (L-network), respectively. Comparison among the general network, H-network and L-network illustrated four conserved combinations: H2BK16Ac ? H3K4me3; H3K14Ac ? H3K4me3; H2AK7Ac ? H3K14Ac; and H4K12Ac ? H3K18Ac. The detailed analysis for some combinations demonstrated that the combinations were ascribed to some histone-modifying enzymes.
|Status: Published||Type: Journal Article||PubMed ID: 21815215|
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