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Lorch Y, et al.  (2011) Selective removal of promoter nucleosomes by the RSC chromatin-remodeling complex.LID - 10.1038/nsmb.2072 [doi] Nat Struct Mol Biol ()

Abstract: Purified chromatin rings, excised from the PHO5 locus of Saccharomyces cerevisiae in transcriptionally repressed and activated states, were remodeled with RSC and ATP. Nucleosomes were translocated, and those originating on the promoter of repressed rings were removed, whereas those originating on the open reading frame (ORF) were retained. Treatment of the repressed rings with histone deacetylase diminished the removal of promoter nucleosomes. These findings point to a principle of promoter chromatin remodeling for transcription, namely that promoter specificity resides primarily in the nucleosomes rather than in the remodeling complex that acts upon them.

Status: Epub ahead of print Type: Journal Article PubMed ID: 21725295

Topics addressed in this paper

Number of different genes curated to this paper: 19

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Topics Genes linked to topics (#1 - 10 )
ARP7 ARP9 HTL1 LDB7 NPL6 PHO5 RSC1 RSC2 RSC3 RSC30
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball
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Protein-Nucleic Acid Interactions blue ball

Topics Genes linked to topics (#11 - 19 )
RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 TAF14
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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