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Lai WK and Buck MJ (2010) ArchAlign: coordinate-free chromatin alignment reveals novel architectures. Genome Biol 11(12):R126
Abstract: To facilitate identification and characterization of genomic functional elements, we have developed a chromatin architecture alignment algorithm (ArchAlign). ArchAlign identifies shared chromatin structural patterns from high-resolution chromatin structural datasets derived from next-generation sequencing or tiled microarray approaches for user defined regions of interest. We validated ArchAlign using well characterized functional elements, and used it to explore the chromatin structural architecture at CTCF binding sites in the human genome. ArchAlign is freely available at http://www.acsu.buffalo.edu/~mjbuck/ArchAlign.html.
| Status: Published | Type: Journal Article | Research Support, U.S. Gov't, Non-P.H.S. | Validation Studies | PubMed ID: 21182771 |
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