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Boyce KJ and Andrianopoulos A  (2011) Ste20-related kinases: effectors of signaling and morphogenesis in fungi. Trends Microbiol 19(8):400-10

Abstract: The family of Ste20-related kinases is conserved from yeast to mammals and includes the p21 activated kinases (PAKs) and germinal centre kinases (GCKs). These kinases have been shown to be involved in signaling through mitogen activated protein kinase (MAPK) pathways and in morphogenesis through the regulation of cytokinesis and actin-dependent polarized growth. This review concentrates on the role of Ste20-related kinases in fungi where recent research has revealed roles for both PAKs and GCKs in the regulation of cytokinesis and in previously unidentified roles in promoting hyphal growth and differentiation of asexual development structures. In particular, the importance of PAKs during pathogenesis will be examined.

Status: Published Type: Journal Article PubMed ID: 21640592

Topics addressed in this paper

Number of different genes curated to this paper: 37

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Topics Genes linked to topics (#1 - 10 )
ACE2 ACT1 ARE2 BEM1 BNI1 BUD6 CBK1 CBR1 CCR4 CDC10
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Topics Genes linked to topics (#11 - 20 )
CDC15 CDC3 CDC36 CDC39 CDC42 CLA4 DBF2 ERG4 KIC1 MOB1
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Topics Genes linked to topics (#21 - 30 )
MOB2 MOT2 MYO2 MYO3 NCP1 NOT3 NOT5 PEA2 POP2 SKM1
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Topics Genes linked to topics (#31 - 37 )
SPA2 SPS1 STE11 STE20 STE4 SUT1 VAC17
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