SGD Paper 
Iwahashi Y and Suzuki T (2011) Gene expression profiles of yeast Saccharomyces cerevisiae sod1 caused by patulin toxicity and evaluation of recovery potential of ascorbic acid. J Agric Food Chem 59(13):7145-54
Abstract: Patulin (PAT) is a fungal secondary metabolite and exhibits various toxicities including DNA damage and oxidative stress. These toxicities are eased by ascorbic acid (AsA). Although a number of studies regarding the mitigating effect of AsA against PAT toxicity have been reported, a comprehensive study about gene expressions is currently underway. Here, we carried out a detailed evaluation of PAT toxicity by co-incubation with AsA using the superoxide dismutase (SOD) mutant. DNA microarray results extracted the alterations in iron transporter and Fe/S cluster assembly genes; some of the genes that constitute the cellular iron transporter systems remained dysfunctional even in the presence of AsA. Meanwhile, AsA treatment reduced the alterations of G1/S phase cell cycle regulation genes. These results suggest that oxidative stress-derived DNA damage still exists, although AsA treatment effectively reduces PAT toxicity. This implies that a combined condition is required for complete blockade of PAT toxicity.
| Status: Published | Type: Journal Article | PubMed ID: 21648421 |
Topics addressed in this paper
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| Topics | Topics not linked to Genes | Genes linked to topics |
|---|---|---|
| SOD1 | ||
| Genomic expression study |  | |
| Infection and Antifungals | | |
| Mutants/Phenotypes | | |
| Omics | 
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| Primary Literature | | |
| Strains/Constructs | |
