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Wilson MA, et al.  (2011) Ubp8 and SAGA regulate Snf1 AMP kinase activity. Mol Cell Biol 31(15):3126-35

Abstract: Posttranslational modifications of histone proteins play important roles in the modulation of gene expression. The Saccharomyces cerevisiae (yeast) 2-MDa SAGA (Spt-Ada-Gcn5) complex, a well-studied multisubunit histone modifier, regulates gene expression through Gcn5-mediated histone acetylation and Ubp8-mediated histone deubiquitination. Using a proteomics approach, we determined that the SAGA complex also deubiquitinates nonhistone proteins, including Snf1, an AMP-activated kinase. Ubp8-mediated deubiquitination of Snf1 affects the stability and phosphorylation state of Snf1, thereby affecting Snf1 kinase activity. Others have reported that Gal83 is phosphorylated by Snf1, and we found that deletion of UBP8 causes decreased phosphorylation of Gal83, which is consistent with the effects of Ubp8 loss on Snf1 kinase functions. Overall, our data indicate that SAGA modulates the posttranslational modifications of Snf1 in order to fine-tune gene expression levels.

Status: Published Type: Journal Article PubMed ID: 21628526

Topics addressed in this paper

Number of different genes curated to this paper: 24

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADA2 CHD1 GAL83 GCN5 HFI1 HTB1 HTB2 NGG1 SGF11 SGF29
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genomic co-immunoprecipitation study yg ball
Genomic expression study yg ball
Large-scale protein detection yg ball
Omics yg ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball
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Techniques and Reagents blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
SGF73 SNF1 SPT20 SPT3 SPT7 SPT8 SUS1 TAF10 TAF12 TAF5
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein Processing/Modification/Regulation blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball
RNA Levels and Processing blue ball
Strains/Constructs blue ball
Substrates/Ligands/Cofactors blue ball

Topics Genes linked to topics (#21 - 24 )
TAF6 TAF9 TRA1 UBP8
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Function/Process blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein-protein Interactions blue ball
Strains/Constructs blue ball
Substrates/Ligands/Cofactors blue ball

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