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Choi JS, et al.  (2011) Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae. Biochem Biophys Res Commun 409(2):308-14

Abstract: Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan.

Status: Published Type: Journal Article PubMed ID: 21575595

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ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP3
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ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX12 COX13
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COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYT1
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Topics Genes linked to topics (#31 - 40 )
ECM14 NDE1 NDE2 NDI1 OLI1 Q0255 QCR10 QCR2 QCR6 QCR7
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QCR9 RIP1 SCEI SDH1 SDH2 SDH3 SDH4 TIM11 VAR1
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