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Hickman MJ, et al.  (2011) The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae. Genetics 188(2):325-38

Abstract: We have studied hypoxic induction of transcription by studying the seripauperin (PAU) genes of Saccharomyces cerevisiae. Previous studies showed that PAU induction requires the depletion of heme and is dependent upon the transcription factor Upc2. We have now identified additional factors required for PAU induction during hypoxia, including Hog1, a mitogen-activated protein kinase (MAPK) whose signaling pathway originates at the membrane. Our results have led to a model in which heme and ergosterol depletion alters membrane fluidity, thereby activating Hog1 for hypoxic induction. Hypoxic activation of Hog1 is distinct from its previously characterized response to osmotic stress, as the two conditions cause different transcriptional consequences. Furthermore, Hog1-dependent hypoxic activation is independent of the S. cerevisiae general stress response. In addition to Hog1, specific components of the SAGA coactivator complex, including Spt20 and Sgf73, are also required for PAU induction. Interestingly, the mammalian ortholog of Spt20, p38IP, has been previously shown to interact with the mammalian ortholog of Hog1, p38. Taken together, our results have uncovered a previously unknown hypoxic-response pathway that may be conserved throughout eukaryotes.

Status: Published Type: Journal Article PubMed ID: 21467572

Topics addressed in this paper

Number of different genes curated to this paper: 56

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADA2 DAN1 ERG25 ERG26 GCN5 GSC2 HEM1 HFI1 HOG1 HSP12
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Topics Genes linked to topics (#11 - 20 )
INO1 MGA2 MSN2 MSN4 NCR1 NGG1 NSG1 NSG2 PAU1 PAU10
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Topics Genes linked to topics (#21 - 30 )
PAU11 PAU12 PAU13 PAU14 PAU15 PAU16 PAU17 PAU18 PAU19 PAU2
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Topics Genes linked to topics (#31 - 40 )
PAU20 PAU21 PAU22 PAU23 PAU24 PAU3 PAU4 PAU5 PAU6 PAU7
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Topics Genes linked to topics (#41 - 50 )
PAU8 PAU9 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SSK1 STE11
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Topics Genes linked to topics (#51 - 56 )
SUS1 TDH1 TFS1 UBP8 UPC2 YSR3
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