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Fasolo J, et al.  (2011) Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Genes Dev 25(7):767-78

Abstract: Protein kinases are key regulators of cellular processes. In spite of considerable effort, a full understanding of the pathways they participate in remains elusive. We globally investigated the proteins that interact with the majority of yeast protein kinases using protein microarrays. Eighty-five kinases were purified and used to probe yeast proteome microarrays. One-thousand-twenty-three interactions were identified, and the vast majority were novel. Coimmunoprecipitation experiments indicate that many of these interactions occurred in vivo. Many novel links of kinases to previously distinct cellular pathways were discovered. For example, the well-studied Kss1 filamentous pathway was found to bind components of diverse cellular pathways, such as those of the stress response pathway and the Ccr4-Not transcriptional/translational regulatory complex; genetic tests revealed that these different components operate in the filamentation pathway in vivo. Overall, our results indicate that kinases operate in a highly interconnected network that coordinates many activities of the proteome. Our results further demonstrate that protein microarrays uncover a diverse set of interactions not observed previously.

Status: Published Type: Journal Article PubMed ID: 21460040

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ACK1 AKL1 APN1 ARK1 ARP8 BCK1 BFR1 BNA1 CAF16 CAK1
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CBK1 CDC15 CDC28 CDC7 CHK1 CLA4 CMK1 CMK2 CRZ1 CTA1
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CTK1 CTK2 DBF2 DBF20 ELM1 FRK1 FUS3 GCN2 GIN4 HAL5
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Topics Genes linked to topics (#31 - 40 )
HRI1 HRR25 HSL1 IPL1 KCC4 KIN1 KIN2 KIN28 KIN3 KIN82
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KKQ8 KSP1 KSS1 MAM33 MCK1 MEK1 MKK1 MPS1 MRK1 NBA1
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NOP53 NPR1 NSL1 PAH1 PBS2 PCL10 PKH2 POF1 PRR1 PRR2
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Topics Genes linked to topics (#61 - 70 )
PRS5 PSK2 PTC1 PTK2 PTP1 RCK1 RCK2 RIM11 RIM9 RIO1
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RKM4 RTK1 SAT4 SCH9 SCT1 SCY1 SIP2 SKM1 SKS1 SKY1
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SLT2 SMK1 SNF1 SNU71 SPS1 SSK2 SSN3 STE11 STE20 STE7
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Topics Genes linked to topics (#91 - 100 )
SWE1 SWM2 TDA1 TIF11 TMT1 TOS3 TPK1 TPK2 TPK3 UBP7
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URA7 VHS1 YAK1 YBR096W YCK2 YCK3 YGK3 YGR017W YKL091C YPK1
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YPK3 YPL150W
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