Wang X, et al. (2011) An effect of DNA sequence on nucleosome occupancy and removal. Nat Struct Mol Biol 18(4):507-9
Abstract: A barrier phases nucleosomes at the yeast (Saccharomyces cerevisiae) GAL1-GAL10 genes. Here we separate nucleosome positioning from occupancy and show that the degree of occupancy of these phased sites is predictably determined by the underlying DNA sequences. As this occupancy is increased (by sequence alteration), nucleosome removal upon induction is decreased, as is mRNA production. These results explain why promoter sequences have evolved to form nucleosomes relatively inefficiently.
|Status: Published||Type: Journal Article||PubMed ID: 21378966|
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