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Cortes-Rojo C, et al.  (2011) Electron transport chain dysfunction by H(2)O (2) is linked to increased reactive oxygen species production and iron mobilization by lipoperoxidation: studies using Saccharomyces cerevisiae mitochondria. J Bioenerg Biomembr 43(2):135-47

Abstract: The mitochondrial electron transport chain (ETC) contains thiol groups (-SH) which are reversibly oxidized to modulate ETC function during H(2)O(2) overproduction. Since deleterious effects of H(2)O(2) are not limited to -SH oxidation, due to the formation of other H(2)O(2)-derived species, some processes like lipoperoxidation could enhance the effects of H(2)O(2) over ETC enzymes, disrupt their modulation by -SH oxidation and increase superoxide production. To verify this hypothesis, we tested the effects of H(2)O(2) on ETC activities, superoxide production and iron mobilization in mitochondria from lipoperoxidation-resistant native yeast and lipoperoxidation-sensitized yeast. Only complex III activity from lipoperoxidation-sensitive mitochondria exhibited a higher susceptibility to H(2)O(2) and increased superoxide production. The recovery of ETC activity by the thiol reductanct ?-mercaptoethanol (BME) was also altered at complex III, and a role was attributed to lipoperoxidation, the latter being also responsible for iron release. A hypothetical model linking lipoperoxidation, increased complex III damage, superoxide production and iron release is given.

Status: Published Type: Journal Article PubMed ID: 21350953

Topics addressed in this paper

Number of different genes curated to this paper: 27

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
COB COR1 COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX5B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism yg ball
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Topics Genes linked to topics (#11 - 20 )
COX6 COX7 COX8 COX9 CYT1 EMI5 QCR10 QCR2 QCR6 QCR7
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Topics Genes linked to topics (#21 - 27 )
QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4
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