SGD Paper 
Chial HJ and Winey M (1999) Mechanisms of genetic instability revealed by analysis of yeast spindle pole body duplication. Biol Cell 91(6):439-50
Abstract: Aneuploidy and polyploidy are commonly observed in transformed cells. These states arise from failures during mitotic chromosome segregation, some of which can be traced to defects in the function or duplication of the centrosome. The centrosome is the organizing center for the mitotic spindle, and the equivalent organelle in the budding yeast, Saccharomyces cerevisiae, is the spindle pole body. We review how defects in spindle pole body duplication or function lead to genetic instability in yeast. There are several well documented instances of genetic instability in yeast that can be traced to the spindle pole body, all of which serve as models for genetic instability in transformed cells.
| Status: Published | Type: Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. | Research Support, U.S. Gov't, P.H.S. | Review | PubMed ID: 10519004 |
Topics addressed in this paper
Number of different genes curated to this paper: 34
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
| Topics | Genes linked to topics (#1 - 10 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ASE1 | BEM2 | BIK1 | BUB1 | CDC11 | CDC20 | CDC24 | CDC28 | CDC31 | CDC34 | |
| Reviews |  | | | | | | | | | |
| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CDC37 | CDC4 | CDC53 | DBF2 | DSK2 | ESP1 | HSF1 | IPL1 | KAR1 | MAD1 | |
| Reviews | | | | | | | | | | |
| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MOB1 | MPS1 | MPS2 | NDC1 | PDS1 | RAD23 | RPT4 | SIC1 | SPC110 | SPC42 | |
| Reviews | | | | | | | | | | |
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
