SGD Paper 
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Tyers M and Jorgensen P (2000) Proteolysis and the cell cycle: with this RING I do thee destroy. Curr Opin Genet Dev 10(1):54-64
Abstract: The ubiquitin system drives the cell division cycle by the timely destruction of numerous regulatory proteins. Remarkably, the two main activities that catalyze substrate ubiquitination in the cell cycle, the Skp1-Cdc53/cullin-F-box protein (SCF) complexes and the anaphase-promoting complex/cyclosome (APC/C), define a new superfamily of E3 ubiquitin ligases, all based on related cullin and RING-H2 finger protein subunits. The circuits that interconnect the SCF, APC/C and cyclin-dependent kinase activities form a master oscillator that coordinates the replication and segregation of the genome.
| Status: Published | Type: Journal Article | Research Support, Non-U.S. Gov't | Review | PubMed ID: 10679394 |
Topics addressed in this paper
Number of different genes curated to this paper: 41
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CDC14 | CDC15 | CDC16 | CDC20 | CDC23 | CDC26 | CDC27 | CDC28 | CDC5 | CDH1 | |
| Reviews |  | | | | | | | | | |
| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHK1 | CLB2 | CLB3 | CLB5 | DBF2 | DBF20 | DOC1 | HRT1 | LTE1 | MAD1 | |
| Reviews | | | | | | | | | | |
Jump to Summary Chart for:
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
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The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
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| Topics | Genes linked to topics (#41 ) |
|---|---|
| TEM1 | |
| Reviews | |
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