Tang W, et al. (2011) Friedreich's Ataxia (GAA)(n)*(TTC)(n) Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae. PLoS Genet 7(1):e1001270
Abstract: Expansions of trinucleotide GAA*TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA*TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)*(TTC)(230) stimulate mitotic crossovers in yeast about 10,000-fold relative to a "normal" DNA sequence; (GAA)(n)*(TTC)(n) tracts, however, do not significantly elevate meiotic recombination. Most of the mitotic crossovers are associated with a region of non-reciprocal transfer of information (gene conversion). The major class of recombination events stimulated by (GAA)(n)*(TTC)(n) tracts is a tract-associated double-strand break (DSB) that occurs in unreplicated chromosomes, likely in G1 of the cell cycle. These findings indicate that (GAA)(n)*(TTC)(n) tracts can be a potent source of loss of heterozygosity in yeast.
|Status: Published||Type: Journal Article||PubMed ID: 21249181|
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