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Menetret JF, et al.  (2000) The structure of ribosome-channel complexes engaged in protein translocation. Mol Cell 6(5):1219-32

Abstract: Cotranslational translocation of proteins requires ribosome binding to the Sec61p channel at the endoplasmic reticulum (ER) membrane. We have used electron cryomicroscopy to determine the structures of ribosome-channel complexes in the absence or presence of translocating polypeptide chains. Surprisingly, the structures are similar and contain 3-4 connections between the ribosome and channel that leave a lateral opening into the cytosol. Therefore, the ribosome-channel junction may allow the direct transfer of polypeptides into the channel and provide a path for the egress of some nascent chains into the cytosol. Moreover, complexes solubilized from mammalian ER membranes contain an additional membrane protein that has a large, lumenal protrusion and is intercalated into the wall of the Sec61p channel. Thus, the native channel contains a component that is not essential for translocation.

Status: Published Type: Journal Article | Research Support, U.S. Gov't, P.H.S. PubMed ID: 11106759

Topics addressed in this paper

Number of different genes curated to this paper: 91

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Topics Genes linked to topics (#1 - 10 )
HEF3 RDN18-1 RDN18-2 RDN25-1 RDN25-2 RDN5-1 RDN5-2 RDN5-3 RDN5-4 RDN5-5
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Topics Genes linked to topics (#11 - 20 )
RDN5-6 RDN58-1 RDN58-2 RPL10 RPL11A RPL11B RPL13B RPL15A RPL15B RPL16B
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Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
RPL17B RPL18A RPL18B RPL1A RPL20A RPL20B RPL21B RPL22A RPL22B RPL24B
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Topics Genes linked to topics (#31 - 40 )
RPL25 RPL26A RPL29 RPL3 RPL31B RPL33A RPL33B RPL36A RPL36B RPL37A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
RPL38 RPL39 RPL42A RPL43A RPL43B RPL5 RPL6A RPL6B RPL7B RPL8B
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Topics Genes linked to topics (#51 - 60 )
RPL9B RPP0 RPP2A RPS0A RPS0B RPS10A RPS10B RPS12 RPS14B RPS15
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
RPS16A RPS17A RPS18B RPS19A RPS19B RPS1A RPS1B RPS21B RPS22A RPS22B
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Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#71 - 80 )
RPS23A RPS23B RPS25B RPS28A RPS28B RPS29A RPS3 RPS30A RPS30B RPS31
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#81 - 90 )
RPS4A RPS5 RPS6A RPS7A RPS7B RPS9A SBH1 SEC61 SSS1 TIF5
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Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 )
YEF3
Additional Literature blue ball
Cellular Location blue ball
Protein-protein Interactions blue ball
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