Wilkinson BM, et al. (2010) Sss1p is required to complete protein translocon activation. J Biol Chem 285(42):32671-7
Abstract: Protein translocation across the endoplasmic reticulum membrane occurs at the Sec61 translocon. This has two essential subunits, the channel-forming multispanning membrane protein Sec61p/Sec61alpha and the tail-anchored Sss1p/Sec61gamma, which has been proposed to "clamp" the channel. We have analyzed the function of Sss1p using a series of domain mutants and found that both the cytosolic and transmembrane clamp domains of Sss1p are essential for protein translocation. Our data reveal that the cytosolic domain is required for Sec61p interaction but that the transmembrane clamp domain is required to complete activation of the translocon after precursor targeting to Sec61p.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 20709746|
Topics addressed in this paper
Number of different genes curated to this paper: 5
- To go to the Locus page for a gene, click on the gene name.
|Fungal Related Genes/Proteins|
|Non-Fungal Related Genes/Proteins|
|Protein Sequence Features|