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Teng SC, et al.  (2002) Induction of global stress response in Saccharomyces cerevisiae cells lacking telomerase. Biochem Biophys Res Commun 291(3):714-21

Abstract: Cellular senescence is a major intermediate step from healthy cells toward tumor cells. By using microarrays that simultaneously examine the transcription levels of 6,200 Saccharomyces cerevisiae genes, we show that 45 gene transcript levels are increased and 11 are decreased after exposure to telomere shortening and cellular senescence in a telomerase-deficient mutant. About half of the genes that showed increased expression were found induced under stress, consistent with the notion that critical short telomeres cause stress to cells. Surprisingly, the expression level of telomere recombination genes was not altered suggesting that even though recombination is a means to rescue critically short telomeres, its machinery was not controlled by telomere shortening. The expression of telomere-proximal genes was also analyzed. The possibility of induction of a program to cope with cellular senescence and active telomere-telomere recombination is discussed.CI - (c)2002 Elsevier Science (USA).

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. | Research Support, U.S. Gov't, P.H.S. PubMed ID: 11855849

Topics addressed in this paper

Number of different genes curated to this paper: 60

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD6 ADE17 AIF1 AIM17 ALD3 AMS1 ASG1 ATR1 CRG1 CTT1
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Genomic expression study yg ball
Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
DBP7 DDR2 DHR2 FIT2 FLR1 FMP33 GAD1 GDB1 GLK1 GPG1
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Topics Genes linked to topics (#21 - 30 )
GPH1 HSP12 HSP26 HSP30 HSP42 MDH2 MSC1 NOG2 NQM1 OM45
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Topics Genes linked to topics (#31 - 40 )
PCK1 PGK1 PHO84 PIC2 PIR3 RAD50 RAD51 RAP1 RNR2 RNR4
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Topics Genes linked to topics (#41 - 50 )
RTN2 RTS3 SDP1 SED1 SOL4 TFS1 TLC1 TMA10 TSL1 USV1
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Mutants/Phenotypes blue ball
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Topics Genes linked to topics (#51 - 60 )
UTP9 YFL066C YHR033W YJL132W YLR149C YLR297W YLR346C YNL200C YPL014W YPS6
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Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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  • To go to the Locus page for a gene, click on the gene name.

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