Hartzog GA, et al. (2002) Transcript elongation on a nucleoprotein template. Biochim Biophys Acta 1577(2):276-86
Abstract: Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and histone modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin.
Type: Journal Article | Research Support, U.S. Gov't, P.H.S. | Review
PubMed ID: 12213658
Topics addressed in this paper
Number of different genes curated to this paper: 78
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