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Cristofari G, et al.  (2002) A 5'-3' long-range interaction in Ty1 RNA controls its reverse transcription and retrotransposition. EMBO J 21(16):4368-79

Abstract: LTR-retrotransposons are abundant components of all eukaryotic genomes and appear to be key players in their evolution. They share with retroviruses a reverse transcription step during their replication cycle. To better understand the replication of retrotransposons as well as their similarities to and differences from retroviruses, we set up an in vitro model system to examine minus-strand cDNA synthesis of the yeast Ty1 LTR-retrotransposon. Results show that the 5' and 3' ends of Ty1 genomic RNA interact through 14 nucleotide 5'-3' complementary sequences (CYC sequences). This 5'-3' base pairing results in an efficient initiation of reverse transcription in vitro. Transposition of a marked Ty1 element and Ty1 cDNA synthesis in yeast rely on the ability of the CYC sequences to base pair. This 5'-3' interaction is also supported by phylogenic analysis of all full-length Ty1 and Ty2 elements present in the Saccharomyces cerevisiae genome. These novel findings lead us to propose that circularization of the Ty1 genomic RNA controls initiation of reverse transcription and may limit reverse transcription of defective retroelements.

Status: Published Type: In Vitro | Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 12169639

Topics addressed in this paper

Number of different genes curated to this paper: 44

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Topics Genes linked to topics (#1 - 10 )
YARCTy1-1 YBLWTy1-1 YBLWTy2-1 YBRWTy1-2 YCLWTy2-1 YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRCTy2-1 YDRWTy1-4
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Topics Genes linked to topics (#11 - 20 )
YDRWTy1-5 YDRWTy2-2 YDRWTy2-3 YERCTy1-1 YERCTy1-2 YFLWTy2-1 YGRCTy1-2 YGRCTy1-3 YGRCTy2-1 YGRWTy1-1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
YGRWTy2-2 YHRCTy1-1 YJRWTy1-1 YJRWTy1-2 YLRCTy1-1 YLRCTy2-2 YLRWTy1-2 YLRWTy1-3 YLRWTy2-1 YMLWTy1-1
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Topics Genes linked to topics (#31 - 40 )
YMLWTy1-2 YMRCTy1-3 YMRCTy1-4 YNLCTy1-1 YNLCTy2-1 YNLWTy1-2 YOLWTy1-1 YORCTy2-1 YORWTy1-2 YORWTy2-2
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Evolution blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 44 )
YPLWTy1-1 YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball
Evolution blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball

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