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Grunau S, et al.  (2011) The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Biochem J 434(1):161-170

Abstract: Phosphoinositides are phosphorylated derivatives of the membrane phospholipid phosphatidylinositol (PtdIns) which have emerged as key regulators of many aspects of cellular physiology. We discovered a PtdIns3P synthesizing activity at peroxisomes from baker's yeast and demonstrate that the lipid kinase Vps34p is associated with peroxisomes already during biogenesis. However, Vps34 is required but is not essential for optimal peroxisome biogenesis. The function of Vps34p containing complex I as well as a subset of PtdIns3P binding proteins proved to be mandatory for the regulated degradation of peroxisomes, demonstrating that PtdIns3P-mediated signalling is required for pexophagy.

Status: Published Type: Journal Article PubMed ID: 21121900

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Number of different genes curated to this paper: 33

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Topics Genes linked to topics (#1 - 10 )
ARC1 ATG14 ATG18 ATG20 ATG21 ATG27 BEM1 BEM3 CDC33 EGD2
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Topics Genes linked to topics (#11 - 20 )
FAB1 HSV2 MDM1 MVP1 PEP4 PEP7 PIB1 PIB2 RGD1 SNX3
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Topics Genes linked to topics (#21 - 30 )
SNX41 SPO14 VAM7 VPS15 VPS17 VPS27 VPS30 VPS34 VPS38 VPS5
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Topics Genes linked to topics (#31 - 33 )
YKR078W YPR097W YPT35
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