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Josse L, et al.  (2011) Transcriptomic and phenotypic analysis of the effects of T-2 toxin on Saccharomyces cerevisiae: evidence of mitochondrial involvement. FEMS Yeast Res 11(1):133-50

Abstract: At 5 mug mL(-1), T-2 toxin significantly upregulated the transcription of 281 genes and downregulated 86. Strongly upregulated genes included those involved in redox activity, mitochondrial functions, the response to oxidative stress, and cytoplasmic rRNA transcription and processing. Highly repressed genes have roles in mitochondrial biogenesis, and the expression and stability of cytoplasmic rRNAs. T-2 toxin inhibition of growth was greater in a medium requiring respiration, and was antagonized by antioxidants. T-2 toxin treatment induced reactive oxygen species, caused nucleolytic damage to DNA, probably mitochondrial, and externalization of phosphatidylserine. Deletion mutations causing respiratory deficiency substantially increased toxin tolerance, and deletion of some TOR (target of rapamycin) pathway genes altered T-2 toxin sensitivity. Deletion of FMS1, which plays an indirect role in cytoplasmic protein synthesis, markedly increased toxin tolerance. Overall, the findings suggest that T-2 toxin targets mitochondria, generating oxy-radicals and repressing mitochondrial biogenesis genes, thus inducing oxidative stress and redox enzyme genes, and triggering changes associated with apoptosis. The large transcriptional changes in genes needed for rRNA transcription and expression and the effects of deletion of FMS1 are also consistent with T-2 toxin damage to the cytoplasmic translational mechanism, although it is unclear how this relates to the mitochondrial effects.CI - (c) 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Status: Published Type: Journal Article PubMed ID: 21114626

Topics addressed in this paper

Number of different genes curated to this paper: 98

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD14 AAD16 AAD4 ADE2 ADH2 BDH1 BMS1 BNA2 BNA4 CAF120
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Cell Growth and Metabolism yg ball
Genomic expression study yg ball
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Topics Genes linked to topics (#11 - 20 )
CDC39 COB COX17 CUS1 CWC23 CYT2 DDI3 DMC1 FAP1 FDH1
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Topics Genes linked to topics (#21 - 30 )
FLR1 FMS1 FPR1 FRE2 GCY1 GIP1 GLN3 GND2 GRE1 GRX4
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Topics Genes linked to topics (#31 - 40 )
GTT2 IFM1 ISC10 ISM1 KCC4 LEA1 MCR1 MEF1 MIP6 MRP13
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Topics Genes linked to topics (#41 - 50 )
MRPL13 MTO1 MUD1 MXR1 PAU2 PAU23 PAU5 PET18 PET309 PIN4
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Alias blue ball
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Topics Genes linked to topics (#51 - 60 )
PRP4 PRP42 PRP9 QDR3 RAD9 RAT1 RAX2 RDN37-1 RDN5-1 RML2
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Topics Genes linked to topics (#61 - 70 )
RPO41 RRN10 RRT13 SGA1 SGS1 SHH3 SHH4 SLZ1 SMD1 SML1
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Topics Genes linked to topics (#71 - 80 )
SNR11 SNR13 SNR38 SNR61 SNR75 SNR76 SNR77 SPO21 SUE1 TEP1
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Topics Genes linked to topics (#81 - 90 )
THI11 THI21 THI4 THI74 TIR4 TLC1 TOR1 TRA1 TSA2 UTP20
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Topics Genes linked to topics (#91 - 98 )
VAS1 VHS3 VPS27 WTM2 YER187W YGR066C YJR079W YNR064C
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