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Heyman T, et al.  (2003) The central PPT of the yeast retrotransposon Ty1 is not essential for transposition. J Mol Biol 331(2):315-20

Abstract: The yeast retrotransposon Ty1 has structural and functional similarities to retroviruses. We report here that, as in retroviruses, the plus-strand DNA of Ty1 is synthesized as two segments. A central DNA flap is formed during reverse transcription consecutive to elongation (with strand displacement) of the upstream segment beyond the central polypurine tract (cPPT) until the replication machinery is stopped at the central termination sequence. Comparison of wild-type and cPPT-mutant Ty1 elements shows that the mutant element lacking the central DNA flap is only twofold defective in transposition.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 12888340

Topics addressed in this paper

Number of different genes curated to this paper: 33

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Topics Genes linked to topics (#1 - 10 )
RAD52 SPT3 YARCTy1-1 YBLWTy1-1 YBRWTy1-2 YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRWTy1-4 YDRWTy1-5
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Mutants/Phenotypes blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
YERCTy1-1 YERCTy1-2 YGRCTy1-2 YGRCTy1-3 YGRWTy1-1 YHRCTy1-1 YJRWTy1-1 YJRWTy1-2 YLRCTy1-1 YLRWTy1-2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
YLRWTy1-3 YMLWTy1-1 YMLWTy1-2 YMRCTy1-3 YMRCTy1-4 YNLCTy1-1 YNLWTy1-2 YOLWTy1-1 YORWTy1-2 YPLWTy1-1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 33 )
YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
Additional Literature blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball
Transcription blue ball blue ball blue ball

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