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McGee JS, et al.  (2010) Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair. Nat Struct Mol Biol 17(12):1438-45

Abstract: Telomerase in Saccharomyces cerevisiae binds and preferentially elongates short telomeres, and this process requires the checkpoint kinase Tel1. Here we show that the Mre11 complex bound preferentially to short telomeres, which could explain the preferential binding of Tel1 to these ends. Compared to wild-type length telomeres, short telomeres generated by incomplete replication had low levels of the telomerase inhibitory protein Rif2. Moreover, in the absence of Rif2, Tel1 bound equally well to short and wild-type length telomeres, suggesting that low Rif2 content marks short telomeres for preferential elongation. In congenic strains, a double-strand break bound at least 140 times as much Mec1 in the first cell cycle after breakage as did a short telomere in the same time frame. Binding of replication protein A was also much lower at short telomeres. The absence of Mec1 at short telomeres could explain why they do not trigger a checkpoint-mediated cell-cycle arrest.

Status: Published Type: Journal Article PubMed ID: 21057524

Topics addressed in this paper

Number of different genes curated to this paper: 16

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Topics Genes linked to topics (#1 - 10 )
CDC13 MEC1 MRE11 RAD50 RAP1 RFA1 RIF1 RIF2 SML1 TEL06R
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Topics Genes linked to topics (#11 - 16 )
TEL07L TEL1 TEL15L TLC1 XRS2 YKU80
Additional Literature blue ball blue ball
Cellular Location blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball
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