Conde J (2003) Twofold symmetries in nucleotide distribution in large domains of Saccharomyces cerevisiae Chromosome I. Mol Genet Genomics 270(4):287-95
Abstract: Single stranded chains of biological DNA show a widespread occurrence of parity for complementary nucleotides, i.e., A=T, G=C. This has been referred to as A-T, G-C symmetry. A distinction must be made between this, which this paper calls mirror symmetry, and twofold symmetry, where complementary nucleotide parity occurs between two segments, of the same length and equidistant from a symmetry center, along a single-stranded DNA chain. I have analysed the sequence of Chromosome I of Saccharomyces cerevisiae for the occurrence of complementary nucleotide symmetry. Open reading frame (ORF) sequences made up 63% of the total chromosome length and most of them were asymmetric for both A-T and G-C. The sign of A-T asymmetry was correlated with transcriptional orientation (A>T for sense and A
Type: Journal Article PubMed ID: 14600830
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