Hernandez H, et al. (2011) Hap2-3-5-Gln3 determine transcriptional activation of GDH1 and ASN1 under repressive nitrogen conditions in the yeast Saccharomyces cerevisiae. Microbiology 157(Pt 3):879-89
Abstract: The transcriptional activation response relies on a repertoire of transcriptional activators, which decipher regulatory information through their specific binding to cognate sequences, and their capacity to selectively recruit the components that constitute a given transcriptional complex. We have addressed the possibility of achieving novel transcriptional responses by the building up a new transcriptional regulator constituted by the Hap2-3-5-Gln3 hybrid modulator, harbouring the HAP complex polypeptides which constitute the DNA binding domain (Hap2-3-5) and the Gln3 activation domain, which customarily act in an uncombined fashion. Results presented herein show that GDH1 and ASN1 transcriptional activation under a nitrogen repressive condition is achieved through the action of the novel Hap2-3-5-Gln3 transcriptional regulator. We propose that the combination of Hap-DNA-binding and Gln3 activation domain results in the constitution of a hybrid modulator that elicits novel transcriptional response not evoked when these modulators act in a non-combinatorial fashion.
|Status: Published||Type: Journal Article||PubMed ID: 21051484|
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