Armache JP, et al. (2010) Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A 107(46):19748-19753
Abstract: Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-A resolution. This map, together with a 6.1-A map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model approximately 98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.
| Status: Published | Type: Journal Article | PubMed ID: 20980660 |
Topics addressed in this paper
Number of different genes curated to this paper: 168
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| Topics | Genes linked to topics (#1 - 10 ) | |||||||||
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| ANB1 | ASC1 | FES1 | FUN12 | GCN1 | GCN2 | GCN20 | HEF3 | HYP2 | MAP1 | |
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NIP7 | PAT1 | RDN18-1 | RDN18-2 | RDN25-1 | RDN25-2 | RDN5-1 | RDN5-2 | RDN5-3 | RDN5-4 | |
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| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RDN5-5 | RDN5-6 | RDN58-1 | RDN58-2 | RLI1 | RPL10 | RPL11A | RPL11B | RPL12A | RPL12B | |
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| Protein/Nucleic Acid Structure | | | | | | | | | | |
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| Topics | Genes linked to topics (#31 - 40 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL13A | RPL13B | RPL14A | RPL14B | RPL15A | RPL15B | RPL16A | RPL16B | RPL17A | RPL17B | |
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| Topics | Genes linked to topics (#41 - 50 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL18A | RPL18B | RPL19A | RPL19B | RPL1A | RPL1B | RPL20A | RPL20B | RPL21A | RPL21B | |
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| Topics | Genes linked to topics (#51 - 60 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL22A | RPL22B | RPL23A | RPL23B | RPL24A | RPL24B | RPL25 | RPL26A | RPL26B | RPL27A | |
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| Topics | Genes linked to topics (#61 - 70 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL27B | RPL28 | RPL29 | RPL2A | RPL2B | RPL3 | RPL30 | RPL31A | RPL31B | RPL32 | |
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| Topics | Genes linked to topics (#71 - 80 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL33A | RPL33B | RPL34A | RPL34B | RPL35A | RPL35B | RPL36A | RPL36B | RPL37A | RPL37B | |
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| Topics | Genes linked to topics (#81 - 90 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL38 | RPL39 | RPL40A | RPL40B | RPL41A | RPL41B | RPL42A | RPL42B | RPL43A | RPL43B | |
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| Topics | Genes linked to topics (#91 - 100 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL4A | RPL4B | RPL5 | RPL6A | RPL6B | RPL7A | RPL7B | RPL8A | RPL8B | RPL9A | |
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| Topics | Genes linked to topics (#101 - 110 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPL9B | RPP0 | RPP1A | RPP1B | RPP2A | RPP2B | RPS0A | RPS0B | RPS10A | RPS10B | |
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| Topics | Genes linked to topics (#111 - 120 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPS11A | RPS11B | RPS12 | RPS13 | RPS14A | RPS14B | RPS15 | RPS16A | RPS16B | RPS17A | |
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| Protein/Nucleic Acid Structure | | | | | | | | | | |
| Topics | Genes linked to topics (#121 - 130 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPS17B | RPS18A | RPS18B | RPS19A | RPS19B | RPS1A | RPS1B | RPS2 | RPS20 | RPS21A | |
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| Topics | Genes linked to topics (#131 - 140 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPS21B | RPS22A | RPS22B | RPS23A | RPS23B | RPS24A | RPS24B | RPS25A | RPS25B | RPS26A | |
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| Topics | Genes linked to topics (#141 - 150 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPS26B | RPS27A | RPS27B | RPS28A | RPS28B | RPS29A | RPS29B | RPS3 | RPS30A | RPS30B | |
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| Topics | Genes linked to topics (#151 - 160 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPS31 | RPS4A | RPS4B | RPS5 | RPS6A | RPS6B | RPS7A | RPS7B | RPS8A | RPS8B | |
| Additional Literature | | | | | | | | | | |
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| Protein/Nucleic Acid Structure | | | | | | | | | | |
| Topics | Genes linked to topics (#161 - 168 ) | |||||||
|---|---|---|---|---|---|---|---|---|
| RPS9A | RPS9B | SIS1 | SQT1 | STM1 | TIF5 | YEF3 | YGR054W | |
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