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Armache JP, et al.  (2010) Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A 107(46):19748-19753

Abstract: Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-A resolution. This map, together with a 6.1-A map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model approximately 98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.

Status: Published Type: Journal Article PubMed ID: 20980660

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ANB1 ASC1 FES1 FUN12 GCN1 GCN2 GCN20 HEF3 HYP2 MAP1
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NIP7 PAT1 RDN18-1 RDN18-2 RDN25-1 RDN25-2 RDN5-1 RDN5-2 RDN5-3 RDN5-4
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RDN5-5 RDN5-6 RDN58-1 RDN58-2 RLI1 RPL10 RPL11A RPL11B RPL12A RPL12B
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RPL13A RPL13B RPL14A RPL14B RPL15A RPL15B RPL16A RPL16B RPL17A RPL17B
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RPL18A RPL18B RPL19A RPL19B RPL1A RPL1B RPL20A RPL20B RPL21A RPL21B
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Topics Genes linked to topics (#61 - 70 )
RPL27B RPL28 RPL29 RPL2A RPL2B RPL3 RPL30 RPL31A RPL31B RPL32
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RPL33A RPL33B RPL34A RPL34B RPL35A RPL35B RPL36A RPL36B RPL37A RPL37B
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RPL38 RPL39 RPL40A RPL40B RPL41A RPL41B RPL42A RPL42B RPL43A RPL43B
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Topics Genes linked to topics (#91 - 100 )
RPL4A RPL4B RPL5 RPL6A RPL6B RPL7A RPL7B RPL8A RPL8B RPL9A
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Topics Genes linked to topics (#101 - 110 )
RPL9B RPP0 RPP1A RPP1B RPP2A RPP2B RPS0A RPS0B RPS10A RPS10B
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Topics Genes linked to topics (#111 - 120 )
RPS11A RPS11B RPS12 RPS13 RPS14A RPS14B RPS15 RPS16A RPS16B RPS17A
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Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#121 - 130 )
RPS17B RPS18A RPS18B RPS19A RPS19B RPS1A RPS1B RPS2 RPS20 RPS21A
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Topics Genes linked to topics (#131 - 140 )
RPS21B RPS22A RPS22B RPS23A RPS23B RPS24A RPS24B RPS25A RPS25B RPS26A
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Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#141 - 150 )
RPS26B RPS27A RPS27B RPS28A RPS28B RPS29A RPS29B RPS3 RPS30A RPS30B
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Topics Genes linked to topics (#151 - 160 )
RPS31 RPS4A RPS4B RPS5 RPS6A RPS6B RPS7A RPS7B RPS8A RPS8B
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Topics Genes linked to topics (#161 - 168 )
RPS9A RPS9B SIS1 SQT1 STM1 TIF5 YEF3 YGR054W
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