Rape M and Jentsch S (2004) Productive RUPture: activation of transcription factors by proteasomal processing. Biochim Biophys Acta 1695(1-3):209-13
Abstract: Proteasomes usually degrade proteins completely into small peptides. In a few cases, however, proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process, termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review, we summarize the available data and suggest a mechanistic model for proteasomal processing.
|Status: Published||Type: Journal Article | Review||PubMed ID: 15571816|
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