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Yadav V, et al.  (2011) Chlorophenol stress affects aromatic amino acid biosynthesis-a genome-wide study. Yeast 28(1):81-91

Abstract: Chlorophenols are a class of chemicals commonly used in preservatives, disinfectants, algaecides, herbicides and pesticides. However, there is a growing evidence that these compounds are a threat to human health. This is alarming as many chlorophenols are common pollutants found in the global environment at potentially biohazardous levels. Despite chlorophenols being abundant, widely used and poisonous, we know relatively little about their mechanism of toxicity in eukaryotes. Thus, we performed genome-wide growth screens using Saccharomyces cerevisiae to understand the molecular basis of chlorophenol toxicity. Of approximately 4850 single gene knockout strains tested, 393 mutants showed growth sensitivity to treatment with 4-chlorophenol (4-CP), 2,4-dichlorophenol (2,4-DCP) or pentachlorophenol (PCP). Only eight mutants showed growth hypersensitivity to all the three treatments and harboured deletions in genes important for aromatic amino acid biosynthesis (ARO1, ARO7) or mitochondrial protein synthesis and respiration (ATP5, ISA1, RML2, GET2, SLS1, MRPL38). Copyright (c) 2010 John Wiley & Sons, Ltd.

Status: Published Type: Journal Article PubMed ID: 20967895

Topics addressed in this paper

Number of different genes curated to this paper: 97

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABF2 AEP1 AIM10 ANB1 ARO1 ARO7 ATP15 ATP5 ATP7 CLC1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Infection and Antifungals yg ball
Large-scale phenotype analysis yg ball
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Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
CYS3 CYS4 DBP7 DIA4 FUN12 FZO1 GET2 HCR1 IFM1 IMG2
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Topics Genes linked to topics (#21 - 30 )
ISA1 MDM10 MMM1 MRP10 MRP17 MRP20 MRP21 MRP51 MRP7 MRPL10
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Topics Genes linked to topics (#31 - 40 )
MRPL13 MRPL15 MRPL16 MRPL17 MRPL22 MRPL32 MRPL33 MRPL36 MRPL37 MRPL38
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Topics Genes linked to topics (#41 - 50 )
MRPL40 MRPL49 MRPL51 MRPL6 MRPS12 MRPS35 MRPS5 MSD1 MSE1 MSK1
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Topics Genes linked to topics (#51 - 60 )
MSM1 MSR1 MSS51 MST1 MSW1 MTF2 MTG1 NAM2 NUP120 NUP133
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Topics Genes linked to topics (#61 - 70 )
NUP84 PET123 PRO1 PRO2 PUT3 RML2 RPL13B RPL14A RPL17B RPL37A
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Topics Genes linked to topics (#71 - 80 )
RPL39 RPO41 RPP2B RPS10A RPS24A RPS26B RPS29A RPS7A RPS9B RSA1
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Topics Genes linked to topics (#81 - 90 )
RSM18 RSM19 RSM22 RSM27 RSM7 SHP1 SLM5 SLS1 SPT7 SSZ1
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Topics Genes linked to topics (#91 - 97 )
SWS2 TUF1 UPS3 VMA11 VMA7 VPH2 YME1
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