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Ratnakumar S, et al.  (2011) Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Mol Biosyst 7(1):139-49

Abstract: Saccharomyces cerevisiae can survive extreme desiccation, but the molecular mechanisms are poorly understood. To define genes involved in desiccation tolerance, two complementary genome-wide approaches, phenomics and transcriptomics, have been used, together with a targeted analysis of gene deletion mutants tested individually for their ability to survive drying. Genome-wide phenotypic analyses carried out on a pooled library of single-gene deletion mutants subjected to three cycles of desiccation and re-growth to post-diauxic phase identified about 650 genes that contributed to strain survival in the drying process. Air-drying desiccation-tolerant post-diauxic phase cells significantly altered transcription in 12% of the yeast genome, activating expression of over 450 genes and down-regulating 330. Autophagy processes were significantly over-represented in both the phenomics study and the genes up-regulated on drying, indicating the importance of the clearance of protein aggregates/damaged organelles and the recycling of nutrients for the survival of desiccation in yeast. Functional carbon source sensing networks governed by the PKA, Tor and Snf1 protein kinase complexes were important for the survival of desiccation, as indicated by phenomics, transcriptomics, and individual analyses of mutant strains. Changes in nitrogen metabolism were evident during the drying process and parts of the environmental stress response were activated, repressing ribosome production and inducing genes for coping with oxidative and osmotic stress.

Status: Published Type: Journal Article PubMed ID: 20963216

Topics addressed in this paper

Number of different genes curated to this paper: 125

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACE2 ADA2 AFT2 AGP1 AGP3 AQR1 ARG1 ARG3 ATG1 ATO3
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Genomic expression study yg ball
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Topics Genes linked to topics (#11 - 20 )
BAS1 BCK1 BCY1 BLM10 BMH1 CAR1 CAT8 CHD1 CIN5 COX16
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Topics Genes linked to topics (#21 - 30 )
CYR1 DCS1 DSD1 DUN1 ECM29 FBP26 FHL1 GAP1 GDH1 GIN4
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Topics Genes linked to topics (#31 - 40 )
GIS1 GLN3 GTS1 HAL9 HAP2 HAP4 HAP5 HIR3 HNM1 HOG1
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Topics Genes linked to topics (#41 - 50 )
HOM3 HSM3 HXK2 IMP2' INO1 INO4 IRC25 ISR1 KRE1 KSP1
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Topics Genes linked to topics (#51 - 60 )
KSS1 LEU3 MBP1 MCK1 MED1 MEP1 MIG1 MIR1 MSN1 MSN2
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Topics Genes linked to topics (#61 - 70 )
MSN4 NOP6 NPR1 NPR2 OPI3 PBS2 POC4 PRO3 PTK1 PTK2
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Topics Genes linked to topics (#71 - 80 )
PUT4 RAD1 RAP1 RAS2 REG1 REG2 RGS2 RHR2 RIM15 RPN10
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Topics Genes linked to topics (#81 - 90 )
RTG1 SAK1 SER2 SFP1 SGF11 SIN3 SIN4 SIP1 SIP3 SIP4
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Topics Genes linked to topics (#91 - 100 )
SIR2 SKN7 SKO1 SKY1 SLT2 SNF1 SNF4 SOD1 SOD2 SPT8
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Topics Genes linked to topics (#101 - 110 )
SRB2 SRB8 SSK2 SSN2 SSN3 STB4 STP1 SUB1 SUT1 TAT1
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Topics Genes linked to topics (#111 - 120 )
TCB1 TDH1 THR1 TPK1 TPO4 TSL1 UBI4 UBX2 UME6 URE2
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Topics Genes linked to topics (#121 - 125 )
YAK1 YAP1 YAP3 YHP1 ZAP1
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