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Meusser B, et al. (2005) ERAD: the long road to destruction. Nat Cell Biol 7(8):766-72
Abstract: Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or unassembled proteins from the ER. ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin-proteasome system (UPS). The spatial separation between substrate selection and degradation in ERAD requires substrate transport from the ER to the cytoplasm by a process termed dislocation. In this review, we will summarize advances in various aspects of ERAD and discuss new findings on how substrate dislocation is achieved.
| Status: Published | Type: Journal Article | Research Support, Non-U.S. Gov't | Review | PubMed ID: 16056268 |
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